Radiation-induced DNA single-strand breaks were studied using preheated cultured mouse leukemic cells, L5178Y, exposed to60 Co γ rays under${\rm N}_{2}\text{-}$ and${\rm N}_{2}{\rm O}\text{-saturated}$ conditions. The yields of DNA strand breaks of cells preheated above 50°C for 10 min were higher in${\rm N}_{2}{\rm O}\text{-saturated}$ than${\rm N}_{2}\text{-saturated}$ suspensions, and the maximum${\rm N}_{2}{\rm O}/{\rm N}_{2}$ DNA strand breaks ratio was about 1.6. These results indicated that OH radicals were mainly responsible for the production of DNA strand breaks.

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