Duplicate studies were conducted to determine the effects of repeated exposures to low-level X radiation on the incidence, volume, and latent period of DMBA-induced neoplasms in Syrian hamster cheek pouch epithelium. Doses employed were 0.05 ml of 0.1% 7,12-dimethylbenz[a]anthracene (DMBA) in mineral oil twice weekly for 10 weeks and 20-R head and neck X radiation once weekly for 17 weeks. Animals received either radiation alone, DMBA alone, or simultaneous radiation + DMBA beginning together. Appropriate controls were performed. Radiation alone did not result in any detectable pathology. In one study, the incidence (68 vs 40%) and volumes of tumors were significantly greater in animals receiving radiation + DMBA than in animals receiving DMBA alone. The latent period for earliest tumor appearance was shorter in animals receiving radiation + DMBA than in animals receiving DMBA alone (9 weeks vs 24 weeks). In the repeat study, increased tumor incidence in the radiation + DMBA group was again observed, but without the decrease in tumor latent period. These results are compatible with synergy between low-level X radiation and DMBA in terms of numbers of animals developing tumors, and also with low-level irradiation altering the biological progression of these DMBA-induced tumors. The results are suggestive of low-level X radiation acting as a synergistic cocarcinogen.
Skip Nav Destination
Research Article| December 01 1977
- Views Icon Views
- Share Icon Share
- Search Site
Alan G. Lurie; Enhancement of DMBA Tumorigenesis in Hamster Cheek Pouch Epithelium by Repeated Exposures to Low-Level X Radiation. Radiat Res 1 December 1977; 72 (3): 499–511. doi: https://doi.org/10.2307/3574613
Download citation file:
Citing articles via
Commonalities Between COVID-19 and Radiation Injury
Carmen I. Rios, David R. Cassatt, Brynn A. Hollingsworth, Merriline M. Satyamitra, Yeabsera S. Tadesse, Lanyn P. Taliaferro, Thomas A. Winters, Andrea L. DiCarlo
Low-Dose Radiation Therapy (LDRT) for COVID-19: Benefits or Risks?
Pataje G. Prasanna, Gayle E. Woloschak, Andrea L. DiCarlo, Jeffrey C. Buchsbaum, Dörthe Schaue, Arnab Chakravarti, Francis A. Cucinotta, Silvia C. Formenti, Chandan Guha, Dale J. Hu, Mohammad K. Khan, David G. Kirsch, Sunil Krishnan, Wolfgang W. Leitner, Brian Marples, William McBride, Minesh P. Mehta, Shahin Rafii, Elad Sharon, Julie M. Sullivan, Ralph R. Weichselbaum, Mansoor M. Ahmed, Bhadrasain Vikram, C. Norman Coleman, Kathryn D. Held
Germicidal Efficacy and Mammalian Skin Safety of 222-nm UV Light
Manuela Buonanno, Brian Ponnaiya, David Welch, Milda Stanislauskas, Gerhard Randers-Pehrson, Lubomir Smilenov, Franklin D. Lowy, David M. Owens, David J. Brenner