Flow cytometry and cell sorting techniques have been used together with repeated measurement in an attempt to define better the radiation survival response of asynchronously dividing Chinese hamster V79-171 cells under aerobic and hypoxic conditions. Although the first two decades of cell inactivation have been examined, particular attention has been given to the low-dose range of a few grays, as used in individual radiation therapy treatments. A single linear-quadratic dose-response function was consistently unable to fit both the low-dose and high-dose data satisfactorily, suggesting a two-component response. Separate fitting of the low-dose and high-dose portions of the response yielded α and β values which differed significantly (P = 0.001 to 0.002). The data are consistent with the hypothesis that the observed substructure simply reflects the presence of subpopulations of sensitive (|${\rm G}_{1}\text{-}$|, G2-phase) and resistant (late S-phase) cells, which are resolved in these measurements. These results may have significance for certain situations in radiation therapy and in biophysical modeling of the radiation response.
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September 1991
Research Article|
September 01 1991
The Radiation Response of Asynchronous Cells at Low Dose: Evidence of Substructure
Radiat Res (1991) 127 (3): 248–256.
Citation
Lloyd D. Skarsgard, Isabel Harrison, Ralph E. Durand; The Radiation Response of Asynchronous Cells at Low Dose: Evidence of Substructure. Radiat Res 1 September 1991; 127 (3): 248–256. doi: https://doi.org/10.2307/3577938
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