COVID-19 is a challenge to biosecurity and public health. The speed of vaccine development lags behind that of virus evolution and mutation. To date, no agent has been demonstrated to be fully effective against COVID-19. Therefore, it remains of great urgency to rapidly develop promising therapeutic and diagnostic candidates. Intriguingly, mounting evidence hints at parallel etiologies between SARS-CoV-2 infection and radiation injury. Herein, from the perspectives of immunogenic pathway activation and metabolic alterations, we provide novel evidence of commonalities between these two pathological conditions based on the most recent findings. Since numerous agents have been developed to prevent or reverse radiation injury in the past 70 years to ensure nuclear safety, we also advocate investigating the promising function of radioprotectors and radiomitigators against COVID-19 in clinical settings.
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September 2022
REVIEW|
July 14 2022
Additional Evidence for Commonalities between COVID-19 and Radiation Injury: Novel Insight into COVID-19 Candidate Drugs
Fenghao Geng;
Fenghao Geng
a West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China
b West China Second University Hospital, Sichuan University, Chengdu 610041, China
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Jianhui Chen;
Jianhui Chen
a West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China
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Shaokai Tang;
Shaokai Tang
a West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China
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Edouard I. Azzam;
Edouard I. Azzam
f Radiobiology and Health, Isotopes, Radiobiology & Environment Directorate (IRED), Canadian Nuclear Laboratories (CNL), Chalk River, ON K0J 1J0, Canada
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Jie Zhang;
Jie Zhang
1
c Institute of Preventive Medicine, Fourth Military Medical University, Xi'an 710032, China
1 Corresponding authors: J. Zhang, Institute of Preventive Medicine, Fourth Military Medical University, No. 169 Changle Xi Rd, Xi'an 710032, China; email: zhangjie78@fmmu.edu.cn. S. Zhang, No. 17 South People's Rd, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China; email: zhang.shuyu@hotmail.com.
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Shuyu Zhang
Shuyu Zhang
1
a West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China
b West China Second University Hospital, Sichuan University, Chengdu 610041, China
d Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu 610051, China
e NHC Key Laboratory of Nuclear Technology Medical Transformation, Mianyang Central Hospital, Mianyang 621099, China
1 Corresponding authors: J. Zhang, Institute of Preventive Medicine, Fourth Military Medical University, No. 169 Changle Xi Rd, Xi'an 710032, China; email: zhangjie78@fmmu.edu.cn. S. Zhang, No. 17 South People's Rd, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China; email: zhang.shuyu@hotmail.com.
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Radiat Res (2022) 198 (3): 306–317.
Article history
Received:
March 17 2022
Accepted:
June 14 2022
Citation
Fenghao Geng, Jianhui Chen, Shaokai Tang, Edouard I. Azzam, Jie Zhang, Shuyu Zhang; Additional Evidence for Commonalities between COVID-19 and Radiation Injury: Novel Insight into COVID-19 Candidate Drugs. Radiat Res 1 September 2022; 198 (3): 306–317. doi: https://doi.org/10.1667/RADE-22-00058.1
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