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Summer 2021
ISSN 2331-5180
In this Issue
INTRODUCTION
RADIOBIOLOGY
The Biological Basis for Enhanced Effects of Proton Radiation Therapy Relative to Photon Radiation Therapy for Head and Neck Squamous Cell Carcinoma
Li Wang, MD, PhD; Piero Fossati, MD; Harald Paganetti, PhD; Li Ma, PhD; Maura Gillison, MD, PhD; Jeffrey N. Myers, MD, PhD; Eugen Hug, MD; Steven J. Frank, MD
PHYSICS
Dual-Energy Computed Tomography Proton-Dose Calculation with Scripting and Modified Hounsfield Units
Anthony Kassaee, MS; Chingyun Cheng, PhD; Lingshu Yin, PhD; Wei Zou, PhD; Taoran Li, PhD; Alexander Lin, MD; Samuel Swisher-McClure, MD; John N. Lukens, MD; Robert A. Lustig, MD; Shannon O'Reilly, PhD; Lei Dong, PhD; Roni Hytonen MS; Boon-Keng Kevin Teo, PhD
CLINICAL
PTCOG Head and Neck Subcommittee Consensus Guidelines on Particle Therapy for the Management of Head and Neck Tumors
Alexander Lin, MD; John H. C. Chang, MD; Ryan S. Grover, MD; Frank J. P. Hoebers, MD, PhD; Upendra Parvathaneni, MBBS, FRANZCR; Samir H. Patel, MD; Juliette Thariat, MD, PhD; David J. Thomson, MA, MD, FACR; Johannes A. Langendijk, MD, PhD; Steven J. Frank, MD; on behalf of the International Particle Therapy Co-operative Group (PTCOG) Head and Neck Subcommittee
Proton Therapy for Head and Neck Cancer: A 12-Year, Single-Institution Experience
G. Brandon Gunn, MD; Adam S. Garden, MD; Rong Ye, MSc; Noveen Ausat, BA; Kristina R. Dahlstrom, PhD; William H. Morrison, MD; C. David Fuller, MD, PhD; Jack Phan, MD, PhD; Jay P. Reddy, MD, PhD; Shalin J. Shah, MD; Lauren L. Mayo, MD; Stephen G. Chun, MD; Gregory M. Chronowski, MD; Amy C. Moreno, MD; Jeffery N. Myers, MD, PhD; Ehab Y. Hanna, MD; Bita Esmaeli, MD; Maura L. Gillison, MD, PhD; Renata Ferrarotto, MD; Katherine A. Hutcheson, PhD; Mark S. Chambers, DMD, MS; Lawrence E. Ginsberg, MD; Adel K. El-Naggar, MD, PhD; David I. Rosenthal, MD; Xiaorong Ronald Zhu, PhD; Steven J. Frank, MD
A Systematic Review on Re-irradiation with Charged Particle Beam Therapy in the Management of Locally Recurrent Skull Base and Head and Neck Tumors
Mauricio E. Gamez, M.D; Samir H. Patel, M.D; Lisa A. McGee, M.D; Terence T. Sio, M.D; Mark McDonald, M.D; Jack Phan, M.D; Daniel J. Ma, M.D; Robert L. Foote, M.D; Jean-Claude M. Rwigema, M.D.
Patient-Reported Outcomes after Intensity-Modulated Proton Therapy for Oropharynx Cancer
Houda Bahig, MD, PhD; Brandon G. Gunn, MD; Adam S. Garden, MD; Rong Ye, MSc; Kate Hutcheson, PhD; David I. Rosenthal, MD; Jack Phan, MD, PhD; Clifton D. Fuller, MD, PhD; William H. Morrison, MD, PhD; Jay Paul Reddy, MD, PhD; Sweet Ping Ng, MBBS, FRANZCR; Neil D. Gross, MD; Erich M. Sturgis, MD, MPH; Renata Ferrarotto, MD; Maura Gillison, MD, PhD; Steven J. Frank, MD
Proton Beam Therapy for Head and Neck Carcinoma of Unknown Primary: Toxicity and Quality of Life
Alexander D. Sherry, BS; Dario Pasalic, MD; G. Brandon Gunn, MD; C. David Fuller, MD PhD; Jack Phan, MD PhD; David I. Rosenthal, MD; William H. Morrison, MD; Erich M. Sturgis, MD; Neil D. Gross, MD; Maura L. Gillison, MD PhD; Renata Ferrarotto, MD; Adel K. El-Naggar, MD; Adam S. Garden, MD; Steven J. Frank, MD
Clinical Review of Proton Therapy in the Treatment of Unilateral Head and Neck Cancers
Robert H. Press, MD; Richard L. Bakst, MD; Sonam Sharma, MD; Rafi Kabarriti, MD; Madhur K. Garg, MD, MBA; Brian Yeh, MD; Daphna Y. Gelbum, MD; Shaakir Hasan, DO; J. Isabelle Choi, MD; Chris A. Barker, MD; Arpit M. Chhabra, MD; Charles B. Simone, II, MD FACRO; Nancy Y. Lee, MD, FASTRO
Proton Therapy for Major Salivary Gland Cancer: Clinical Outcomes
Alexander N. Hanania, MD, MPH; Xiaodong Zhang, PhD; G. Brandon Gunn, MD; David I. Rosenthal, MD; Adam S. Garden, MD; C. David Fuller, MD, PhD; Jack Phan, MD, PhD; Jay P. Reddy, MD; Amy Moreno, MD; Gregory Chronowski, MD; Shalin Shah, MD; Noveen Ausat, BA; Ehab Hanna, MD; Renata Ferrarotto, MD; Steven J. Frank, MD
Oncologic Outcomes for Head and Neck Skin Malignancies Treated with Protons
Jidapa Bridhikitti, MD; Jason K. Viehman; W. Scott Harmsen; Adam C. Amundson; Satomi Shiraishi, PhD; Daniel W. Mundy, PhD; Jean-Claude M. Rwigema, MD; Lisa A. McGee, MD; Samir H. Patel, MD; David M. Routman, MD; Scott C. Lester, MD; Michelle A. Neben-Wittich, MD; Yolanda I. Garces, MD; Daniel J. Ma, MD; Robert L. Foote, MD
HEALTH POLICY
Work Outcomes after Intensity-Modulated Proton Therapy (IMPT) versus Intensity-Modulated Photon Therapy (IMRT) for Oropharyngeal Cancer
Grace L. Smith, MD, PhD, MPH; Shuangshuang Fu, PhD; Matthew S. Ning, MD, MPH; Diem-Khanh Nguyen, BA; Paul M. Busse, MD, PhD; Robert L. Foote, MD; Adam S. Garden, MD; Gary B. Gunn, MD; Clifton D. Fuller, MD, PhD; William H. Morrison, MD; Gregory M. Chronowski, MD; Shalin J. Shah, MD; Lauren L. Mayo, MD; Jack Phan, MD, PhD; Jay P. Reddy, PhD; James W. Snider, III, MD; Samir H. Patel, MD; Sanford R. Katz, MD; Alexander Lin, MD; Nasiruddin Mohammed, MD; Roi Dagan, MD, MS; Nancy Y. Lee, MD; David I. Rosenthal, MD; Steven J. Frank, MD
Methodologies to Increase the Level of Evidence of Real-life Proton Therapy in Head and Neck Tumors
Francesco Dionisi, MD; Lamberto Widesott, PhD; Marco Van Vulpen, MD; Clifton David Fuller, MD; Rocco Frondizi, PhD; Marco Meneguzzo; Pierre Blanchard, MD; Maurizio Amichetti, MD; Giuseppe Sanguineti, MD
Cost-Effectiveness Models of Proton Therapy for Head and Neck: Evaluating Quality and Methods to Date
Danmeng Huang, PhD; Steven J. Frank, MD; Vivek Verma, MD; Nikhil G. Thaker, MD; Eric D. Brooks, MD, MHS; Matthew B. Palmer, MBA; Ross F. Harrison, MD, MPH; Ashish A. Deshmukh, PhD, MPH; Matthew S. Ning, MD, MPH
National Protocol for Model-Based Selection for Proton Therapy in Head and Neck Cancer
Johannes A. Langendijk, MD, PhD; Frank J. P. Hoebers, MD, PhD; Martin A. de Jong, MD; Patricia Doornaert, MD, PhD; Chris H. J. Terhaard, MD, PhD; Roel J. H. M. Steenbakkers, MD, PhD; Olga Hamming-Vrieze, MD, PhD; Jeroen B. van de Kamer, PhD; Wilko F. A. R. Verbakel, PhD; Fatma Keskin-Cambay, MD; Johannes B. Reitsma, MD, PhD; Arjen van der Schaaf, PhD; Liesbeth J. Boersma, MD, PhD; Ewoud Schuit, PhD
Activity-Based Costing of Intensity-Modulated Proton versus Photon Therapy for Oropharyngeal Cancer
Nikhil G. Thaker, MD; David Boyce-Fappiano, MD; Matthew S. Ning, MD; Dario Pasalic, MD; Alexis Guzman, MBA; Grace Smith, MD, PhD, MPH; Emma B. Holliday, MD; James Incalcaterra, PhD; Adam S. Garden, MD; Simona F. Shaitelman, MD; G. Brandon Gunn, MD; C. David Fuller, MD, PhD; Pierre Blanchard, MD; Thomas W. Feeley, MD; Robert S. Kaplan, PhD; Steven J. Frank, MD
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Health Care Resource Utilization for Esophageal Cancer Using Proton versus Photon Radiation Therapy
Steven H. Lin, MD, PhD, Kaiping Liao, PhD, Xiudong Lei, PhD, Vivek Verma, MD, Sherif Shaaban, MD, Percy Lee, MD, Aileen B. Chen, MD, Albert C. Koong, MD, PhD, Wayne L. Hoftstetter, MD, Steven J. Frank, MD, Zhongxing Liao, MD, Ya-Chen Tina Shih, PhD, Sharon H. Giordano, MD, Grace L. Smith, MD, PhD, MPH
Comparison of Estimated Late Toxicities between IMPT and IMRT Based on Multivariable NTCP Models for High-Risk Prostate Cancers Treated with Pelvic Nodal Radiation
Srinivas Chilukuri, MD, Sham Sundar, MD, Kartikeswar Patro, MSc, Mayur Sawant, MSc, Rangasamy Sivaraman, MSc, Manikandan Arjunan, PhD, Pankaj Kumar Panda, MSc, Dayananda Sharma, PhD, Rakesh Jalali, MD
A Review of Boron Neutron Capture Therapy: Its History and Current Challenges
Will H. Jin, MD, Crystal Seldon, MD, Michael Butkus, PhD, Wolfgang Sauerwein, MD, Huan B. Giap, MD, PhD
Determination of Integral Depth Dose in Proton Pencil Beam Using Plane-parallel Ionization Chambers
Phatthraporn Thasasi, MSc, Sirinya Ruangchan, PhD, Puntiwa Oonsiri, MSc, Sornjarod Oonsiri, PhD
Brainstem Toxicity in Pediatric Patients Treated with Protons Using a Single-vault Synchrocyclotron System
Inema Orukari, PhD, Stephanie Perkins, MD, Tianyu Zhao, PhD, Jiayi Huang, MD, Douglas F. Caruthers, MS, Sai Duriseti, MD, PhD
