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Summer 2021
ISSN 2331-5180
In this Issue
INTRODUCTION
RADIOBIOLOGY
The Biological Basis for Enhanced Effects of Proton Radiation Therapy Relative to Photon Radiation Therapy for Head and Neck Squamous Cell Carcinoma
Li Wang, MD, PhD; Piero Fossati, MD; Harald Paganetti, PhD; Li Ma, PhD; Maura Gillison, MD, PhD; Jeffrey N. Myers, MD, PhD; Eugen Hug, MD; Steven J. Frank, MD
PHYSICS
Dual-Energy Computed Tomography Proton-Dose Calculation with Scripting and Modified Hounsfield Units
Anthony Kassaee, MS; Chingyun Cheng, PhD; Lingshu Yin, PhD; Wei Zou, PhD; Taoran Li, PhD; Alexander Lin, MD; Samuel Swisher-McClure, MD; John N. Lukens, MD; Robert A. Lustig, MD; Shannon O'Reilly, PhD; Lei Dong, PhD; Roni Hytonen MS; Boon-Keng Kevin Teo, PhD
CLINICAL
PTCOG Head and Neck Subcommittee Consensus Guidelines on Particle Therapy for the Management of Head and Neck Tumors
Alexander Lin, MD; John H. C. Chang, MD; Ryan S. Grover, MD; Frank J. P. Hoebers, MD, PhD; Upendra Parvathaneni, MBBS, FRANZCR; Samir H. Patel, MD; Juliette Thariat, MD, PhD; David J. Thomson, MA, MD, FACR; Johannes A. Langendijk, MD, PhD; Steven J. Frank, MD; on behalf of the International Particle Therapy Co-operative Group (PTCOG) Head and Neck Subcommittee
Proton Therapy for Head and Neck Cancer: A 12-Year, Single-Institution Experience
G. Brandon Gunn, MD; Adam S. Garden, MD; Rong Ye, MSc; Noveen Ausat, BA; Kristina R. Dahlstrom, PhD; William H. Morrison, MD; C. David Fuller, MD, PhD; Jack Phan, MD, PhD; Jay P. Reddy, MD, PhD; Shalin J. Shah, MD; Lauren L. Mayo, MD; Stephen G. Chun, MD; Gregory M. Chronowski, MD; Amy C. Moreno, MD; Jeffery N. Myers, MD, PhD; Ehab Y. Hanna, MD; Bita Esmaeli, MD; Maura L. Gillison, MD, PhD; Renata Ferrarotto, MD; Katherine A. Hutcheson, PhD; Mark S. Chambers, DMD, MS; Lawrence E. Ginsberg, MD; Adel K. El-Naggar, MD, PhD; David I. Rosenthal, MD; Xiaorong Ronald Zhu, PhD; Steven J. Frank, MD
A Systematic Review on Re-irradiation with Charged Particle Beam Therapy in the Management of Locally Recurrent Skull Base and Head and Neck Tumors
Mauricio E. Gamez, M.D; Samir H. Patel, M.D; Lisa A. McGee, M.D; Terence T. Sio, M.D; Mark McDonald, M.D; Jack Phan, M.D; Daniel J. Ma, M.D; Robert L. Foote, M.D; Jean-Claude M. Rwigema, M.D.
Patient-Reported Outcomes after Intensity-Modulated Proton Therapy for Oropharynx Cancer
Houda Bahig, MD, PhD; Brandon G. Gunn, MD; Adam S. Garden, MD; Rong Ye, MSc; Kate Hutcheson, PhD; David I. Rosenthal, MD; Jack Phan, MD, PhD; Clifton D. Fuller, MD, PhD; William H. Morrison, MD, PhD; Jay Paul Reddy, MD, PhD; Sweet Ping Ng, MBBS, FRANZCR; Neil D. Gross, MD; Erich M. Sturgis, MD, MPH; Renata Ferrarotto, MD; Maura Gillison, MD, PhD; Steven J. Frank, MD
Proton Beam Therapy for Head and Neck Carcinoma of Unknown Primary: Toxicity and Quality of Life
Alexander D. Sherry, BS; Dario Pasalic, MD; G. Brandon Gunn, MD; C. David Fuller, MD PhD; Jack Phan, MD PhD; David I. Rosenthal, MD; William H. Morrison, MD; Erich M. Sturgis, MD; Neil D. Gross, MD; Maura L. Gillison, MD PhD; Renata Ferrarotto, MD; Adel K. El-Naggar, MD; Adam S. Garden, MD; Steven J. Frank, MD
Clinical Review of Proton Therapy in the Treatment of Unilateral Head and Neck Cancers
Robert H. Press, MD; Richard L. Bakst, MD; Sonam Sharma, MD; Rafi Kabarriti, MD; Madhur K. Garg, MD, MBA; Brian Yeh, MD; Daphna Y. Gelbum, MD; Shaakir Hasan, DO; J. Isabelle Choi, MD; Chris A. Barker, MD; Arpit M. Chhabra, MD; Charles B. Simone, II, MD FACRO; Nancy Y. Lee, MD, FASTRO
Proton Therapy for Major Salivary Gland Cancer: Clinical Outcomes
Alexander N. Hanania, MD, MPH; Xiaodong Zhang, PhD; G. Brandon Gunn, MD; David I. Rosenthal, MD; Adam S. Garden, MD; C. David Fuller, MD, PhD; Jack Phan, MD, PhD; Jay P. Reddy, MD; Amy Moreno, MD; Gregory Chronowski, MD; Shalin Shah, MD; Noveen Ausat, BA; Ehab Hanna, MD; Renata Ferrarotto, MD; Steven J. Frank, MD
Oncologic Outcomes for Head and Neck Skin Malignancies Treated with Protons
Jidapa Bridhikitti, MD; Jason K. Viehman; W. Scott Harmsen; Adam C. Amundson; Satomi Shiraishi, PhD; Daniel W. Mundy, PhD; Jean-Claude M. Rwigema, MD; Lisa A. McGee, MD; Samir H. Patel, MD; David M. Routman, MD; Scott C. Lester, MD; Michelle A. Neben-Wittich, MD; Yolanda I. Garces, MD; Daniel J. Ma, MD; Robert L. Foote, MD
HEALTH POLICY
Work Outcomes after Intensity-Modulated Proton Therapy (IMPT) versus Intensity-Modulated Photon Therapy (IMRT) for Oropharyngeal Cancer
Grace L. Smith, MD, PhD, MPH; Shuangshuang Fu, PhD; Matthew S. Ning, MD, MPH; Diem-Khanh Nguyen, BA; Paul M. Busse, MD, PhD; Robert L. Foote, MD; Adam S. Garden, MD; Gary B. Gunn, MD; Clifton D. Fuller, MD, PhD; William H. Morrison, MD; Gregory M. Chronowski, MD; Shalin J. Shah, MD; Lauren L. Mayo, MD; Jack Phan, MD, PhD; Jay P. Reddy, PhD; James W. Snider, III, MD; Samir H. Patel, MD; Sanford R. Katz, MD; Alexander Lin, MD; Nasiruddin Mohammed, MD; Roi Dagan, MD, MS; Nancy Y. Lee, MD; David I. Rosenthal, MD; Steven J. Frank, MD
Methodologies to Increase the Level of Evidence of Real-life Proton Therapy in Head and Neck Tumors
Francesco Dionisi, MD; Lamberto Widesott, PhD; Marco Van Vulpen, MD; Clifton David Fuller, MD; Rocco Frondizi, PhD; Marco Meneguzzo; Pierre Blanchard, MD; Maurizio Amichetti, MD; Giuseppe Sanguineti, MD
Cost-Effectiveness Models of Proton Therapy for Head and Neck: Evaluating Quality and Methods to Date
Danmeng Huang, PhD; Steven J. Frank, MD; Vivek Verma, MD; Nikhil G. Thaker, MD; Eric D. Brooks, MD, MHS; Matthew B. Palmer, MBA; Ross F. Harrison, MD, MPH; Ashish A. Deshmukh, PhD, MPH; Matthew S. Ning, MD, MPH
National Protocol for Model-Based Selection for Proton Therapy in Head and Neck Cancer
Johannes A. Langendijk, MD, PhD; Frank J. P. Hoebers, MD, PhD; Martin A. de Jong, MD; Patricia Doornaert, MD, PhD; Chris H. J. Terhaard, MD, PhD; Roel J. H. M. Steenbakkers, MD, PhD; Olga Hamming-Vrieze, MD, PhD; Jeroen B. van de Kamer, PhD; Wilko F. A. R. Verbakel, PhD; Fatma Keskin-Cambay, MD; Johannes B. Reitsma, MD, PhD; Arjen van der Schaaf, PhD; Liesbeth J. Boersma, MD, PhD; Ewoud Schuit, PhD
Activity-Based Costing of Intensity-Modulated Proton versus Photon Therapy for Oropharyngeal Cancer
Nikhil G. Thaker, MD; David Boyce-Fappiano, MD; Matthew S. Ning, MD; Dario Pasalic, MD; Alexis Guzman, MBA; Grace Smith, MD, PhD, MPH; Emma B. Holliday, MD; James Incalcaterra, PhD; Adam S. Garden, MD; Simona F. Shaitelman, MD; G. Brandon Gunn, MD; C. David Fuller, MD, PhD; Pierre Blanchard, MD; Thomas W. Feeley, MD; Robert S. Kaplan, PhD; Steven J. Frank, MD
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Comparative Effectiveness of Proton Therapy versus Photon Radiotherapy in Adolescents and Young Adults for Classical Hodgkin Lymphoma
James E. Bates, MD, Stephanie Terezakis, MD, Christopher G. Morris, MS, Avani D. Rao, MD, Shuchi Sehgal, BA, Rahul Kumar, MBBS, Raymond B. Mailhot Vega, MD, MPH, Nancy P. Mendenhall, MD, Bradford S. Hoppe, MD, MPH
Bone Marrow Suppression during Postoperative Radiation for Bladder Cancer and Comparative Benefit of Proton Therapy—Phase 2 Trial Secondary Analysis
Robert H. Press, MD, Joseph W. Shelton, MD, Chao Zhang, PhD, Quang Dang, CMD, Sibo Tian, MD, Timothy Shu, MPH, Crystal S. Seldon, MD, Shaakir Hasan, DO, Ashesh B. Jani, MD, FASTRO, Jun Zhou, PhD, Mark W. McDonald, MD
Proton Beam Therapy for Head and Neck Carcinoma of Unknown Primary: Toxicity and Quality of Life
Alexander D. Sherry, BS, Dario Pasalic, MD, G. Brandon Gunn, MD, C. David Fuller, MD PhD, Jack Phan, MD PhD, David I. Rosenthal, MD, William H. Morrison, MD, Erich M. Sturgis, MD, Neil D. Gross, MD, Maura L. Gillison, MD PhD, Renata Ferrarotto, MD, Adel K. El-Naggar, MD, Adam S. Garden, MD, Steven J. Frank, MD
National Protocol for Model-Based Selection for Proton Therapy in Head and Neck Cancer
Johannes A. Langendijk, MD, PhD, Frank J. P. Hoebers, MD, PhD, Martin A. de Jong, MD, Patricia Doornaert, MD, PhD, Chris H. J. Terhaard, MD, PhD, Roel J. H. M. Steenbakkers, MD, PhD, Olga Hamming-Vrieze, MD, PhD, Jeroen B. van de Kamer, PhD, Wilko F. A. R. Verbakel, PhD, Fatma Keskin-Cambay, MD, Johannes B. Reitsma, MD, PhD, Arjen van der Schaaf, PhD, Liesbeth J. Boersma, MD, PhD, Ewoud Schuit, PhD
A Systematic Review on Re-irradiation with Charged Particle Beam Therapy in the Management of Locally Recurrent Skull Base and Head and Neck Tumors
Mauricio E. Gamez, M.D, Samir H. Patel, M.D, Lisa A. McGee, M.D, Terence T. Sio, M.D, Mark McDonald, M.D, Jack Phan, M.D, Daniel J. Ma, M.D, Robert L. Foote, M.D, Jean-Claude M. Rwigema, M.D.
