Improved hand and arm function is the most sought after function for people living with a cervical spinal cord injury (SCI). Surgical techniques have been established to increase upper extremity function for tetraplegics, focusing on restoring elbow extension, wrist movement, and hand opening and closing. Additionally, more innovative treatments that have been developed (implanted neuroprostheses and nerve transfers) provide more options for improving function and quality of life. One of the most important steps in the process of restoring upper extremity function in people with tetraplegia is identifying appropriate candidates – typically those with American Spinal Injury Association (ASIA) motor level C5 or greater. Secondary complications of SCI can pose barriers to restoring function, particularly upper extremity spasticity. A novel approach to managing spasticity through high-frequency alternating currents designed to block unwanted spasticity is being researched at the Cleveland FES Center and may improve the impact of reconstructive surgery for these individuals. The impact of these surgeries is best measured within the framework of the World Health Organization’s International Classification of Function, Disability and Health. Outcome measures should be chosen to reflect changes within the domains of body functions and structures, activity, and participation. There is a need to strengthen the evidence in the area of reconstructive procedures for people with tetraplegia. Research continues to advance, providing more options for improved function in this population than ever before. The contribution of well-designed outcome studies to this evidence base will ultimately help to address the complications surrounding access to the procedures.

Spinal Cord Injury Facts & Figures at a Glance 2011. https://www.nscisc.uab.edu. Birmingham, Alabama: National Spinal Cord Injury Statistical Center; February 2011. www.nscisc.uab.edu
Anderson KD. Targeting recovery: priorities of the spinal cord-injured population. J Neurotrauma. 2004;21(10):1371-1383.
,
Targeting recovery: priorities of the spinal cord-injured population
,
J Neurotrauma.
, vol.
21
(pg.
1371
-
1383
)
Snoek GJ, Ijzerman MJ, Hermens HJ, Maxwell D, Biering-Sorensen F. Survey of the needs of patients with spinal cord injury: impact and priority for improvement in hand function in tetraplegics. Spinal Cord. 2004;42:526-532.
,
Survey of the needs of patients with spinal cord injury: impact and priority for improvement in hand function in tetraplegics
,
Spinal Cord.
, vol.
42
(pg.
526
-
532
)
Keith MW, Lacey SH. Surgical rehabilitation of the tetraplegic upper extremity. J Neuro Rehabil. 1991;5(1&2):75-87.
,
Surgical rehabilitation of the tetraplegic upper extremity
,
J Neuro Rehabil.
, vol.
5
(pg.
75
-
87
)
Friden J, Reinholdt C. Current concepts in reconstruction of hand function in tetraplegia. Scand J Surg. 2008;97:341-346.
,
Current concepts in reconstruction of hand function in tetraplegia
,
Scand J Surg.
, vol.
97
(pg.
341
-
346
)
Kozin SH, D’Addesi L, Chafetz RS, Ashworth S, Mulcahey MJ. Biceps-to-triceps transfer for elbow extension in persons with tetraplegia. J Hand Surg. 2010;35A:968-975.
,
Biceps-to-triceps transfer for elbow extension in persons with tetraplegia
,
J Hand Surg.
, vol.
35A
(pg.
968
-
975
)
Ainsley J, Voorhees C, Drake E. Reconstructive surgery for quadriplegic persons. Am J Occup Ther. 1985;39:715-721.
,
Reconstructive surgery for quadriplegic persons
,
Am J Occup Ther.
, vol.
39
(pg.
715
-
721
)
Peljovich AE, Bryden AM, Malone K, Hoyen HA, Hernandez-Gonzalez E, Keith MW. Rehabilitation of the hand and upper extremity in tetraplegia. In: Skirven TM, Osterman AL, Fedorczyk JM, Amadio PC, eds. Rehabilitation of the Hand and Upper Extremity. 6th ed. Philadelphia, PA: Elsevier Mosby; 2011.
,
Rehabilitation of the hand and upper extremity in tetraplegia
,
Rehabilitation of the Hand and Upper Extremity.
Kilgore KL, Hoyen HA, Bryden AM, Hart RL, Keith MW, Peckham PH. An implanted upper-extremity neuroprosthesis using myoelectric control. J Hand Surg. 2008;33A:539-550.
,
An implanted upper-extremity neuroprosthesis using myoelectric control
,
J Hand Surg.
, vol.
33A
(pg.
539
-
550
)
Waters RL, Sie IH, Gellman H, Tognella M. Functional hand surgery following tetraplegia. Arch Phys Med Rehabil., 1996;77(1):86-94.
,
Functional hand surgery following tetraplegia
,
Arch Phys Med Rehabil.
, vol.
77
(pg.
86
-
94
)
Bryden AM, Kilgore KL, Lind BB, Yu DT. Triceps denervation as a predictor of elbow flexion contractures in C5 and C6 tetraplegia. Arch Phys Med Rehabil. 2004;85:1880-1885.
,
Triceps denervation as a predictor of elbow flexion contractures in C5 and C6 tetraplegia
,
Arch Phys Med Rehabil.
, vol.
85
(pg.
1880
-
1885
)
Curtin CM, Wagner JP, Gater DR, Chung KC. Opinions on the treatment of people with tetraplegia: contrasting perceptions of physiatrists and hand surgeons. J Spinal Cord Med. 2007;30(3):256-262.
,
Opinions on the treatment of people with tetraplegia: contrasting perceptions of physiatrists and hand surgeons
,
J Spinal Cord Med.
, vol.
30
(pg.
256
-
262
)
Curtin CM, Gater DR, Chung KC. Upper extremity reconstruction in the tetraplegion population, a national epidemiologic study. J Hand Surg. 2005;30A:94-99.
,
Upper extremity reconstruction in the tetraplegion population, a national epidemiologic study
,
J Hand Surg.
, vol.
30A
(pg.
94
-
99
)
Curtin CM, Hayward RA, Kim HM, Gater DR, Chung KC. Physician perceptions of upper extremity reconstruction for the person with tetraplegia. J Hand Surg. 2005;30A:87-93.
,
Physician perceptions of upper extremity reconstruction for the person with tetraplegia
,
J Hand Surg.
, vol.
30A
(pg.
87
-
93
)
Moberg E. Surgical treatment for absent single-hand grip and elbow extension in quadriplegia. Principles and preliminary experience. J Bone Joint Surg. 1975;57A:196-206.
,
Surgical treatment for absent single-hand grip and elbow extension in quadriplegia. Principles and preliminary experience
,
J Bone Joint Surg.
, vol.
57A
(pg.
196
-
206
)
Hentz VR, Keoshian LA. Changing perspectives in surgical hand rehabilitation in quadriplegic patients. Plast Reconstr Surg. 1979;64:509-515.
,
Changing perspectives in surgical hand rehabilitation in quadriplegic patients
,
Plast Reconstr Surg.
, vol.
64
(pg.
509
-
515
)
American Spinal Injury Association. International Standards for Neurological and Functional Classification of Spinal Cord Injury. Chicago, IL: Author; 2006.
,
American Spinal Injury Association
,
International Standards for Neurological and Functional Classification of Spinal Cord Injury.
McDowell CL, Moberg EA, House JH. The Second International Conference on Surgical Rehabilitation of the Upper Limb in Tetraplegia (Quadriplegia). J Hand Surg. 1986;11(A):604-608.
,
The Second International Conference on Surgical Rehabilitation of the Upper Limb in Tetraplegia (Quadriplegia)
,
J Hand Surg.
, vol.
11
(pg.
604
-
608
)
Mulcahey MJ, Lutz C, Kozin SH, Betz RR. Prospective evaluation of biceps to triceps and deltoid to triceps for elbow extension in tetraplegia. J Hand Surg. 2003;28A:964-971.
,
Prospective evaluation of biceps to triceps and deltoid to triceps for elbow extension in tetraplegia
,
J Hand Surg.
, vol.
28A
(pg.
964
-
971
)
Kilgore KL, Peckham PH, Crish TJ, Smith B, inventors; Case Western Reserve University, assignee. Implantable networked neural system. US patent 7,260,436. August 21, 2007.
Peckham P, Kilgore K, Smith B, Campean A, Buckett J, Vrabec T. Development of networked implantable neuroprostheses. In: Proceedings of the National Institutes of Health 7th Annual BRP Grantee Meeting; Bethesda, MD; 2007.
Birch R. Brachial plexus injuries. J Bone Joint Surg. 1996;78B:986-992.
,
Brachial plexus injuries
,
J Bone Joint Surg.
, vol.
78B
(pg.
986
-
992
)
Malessy MJ, Thomeer RT. Evaluation of intercostal to musculocutaneous nerve transfer in reconstructive brachial plexus surgery. J Neurosurg. 1998;88:266-271.
,
Evaluation of intercostal to musculocutaneous nerve transfer in reconstructive brachial plexus surgery
,
J Neurosurg.
, vol.
88
(pg.
266
-
271
)
Chuang DC, Lee GW, Hashem F, Wei FC. Restoration of shoulder abduction by nerve transfer in avulsed brachial plexus injury: evaluation of 99 patients with various nerve transfers. Plast Reconstr Surg. 1995;96:122-128.
,
Restoration of shoulder abduction by nerve transfer in avulsed brachial plexus injury: evaluation of 99 patients with various nerve transfers
,
Plast Reconstr Surg.
, vol.
96
(pg.
122
-
128
)
Samii M, Carvalho GA, Nikkhah G, Penkert G. Surgical reconstruction of the musculocutaneous nerve in traumatic brachial plexus injuries. J Neurosurg. 1997;87:881-886.
,
Surgical reconstruction of the musculocutaneous nerve in traumatic brachial plexus injuries
,
J Neurosurg.
, vol.
87
(pg.
881
-
886
)
Klotz R, Joseph PA, Ravaud JF, Wiart L, Barat M; The Tetrafigap Group. The Tetrafigap Survey on the long-term outcome of tetraplegic spinal cord injured persons: Part III. Medical complications and associated factors. Spinal Cord. 2002;40:457-467.
,
The Tetrafigap Group. The Tetrafigap Survey on the long-term outcome of tetraplegic spinal cord injured persons: Part III. Medical complications and associated factors
,
Spinal Cord.
, vol.
40
(pg.
457
-
467
)
Gracies JM, Nance P, Elovic E, McGuire J, Simpson DM. Traditional pharmacological treatments for spasticity. Part II: General and regional treatments. Muscle Nerve Suppl. 1997;6:S92-120.
,
Traditional pharmacological treatments for spasticity. Part II: General and regional treatments
,
Muscle Nerve Suppl.
, vol.
6
(pg.
S92
-
120
)
Dario A, Scamoni C, Picano M, Casagrande F, Tomei G. Pharmacological complications of the chronic baclofen infusion in the severe spinal spasticity. Personal experience and review of the literature. J Neurosurg Sci. 2004;48(4):177-181.
,
Pharmacological complications of the chronic baclofen infusion in the severe spinal spasticity. Personal experience and review of the literature
,
J Neurosurg Sci.
, vol.
48
(pg.
177
-
181
)
Al-Khodairy AT, Gobelet C, Rossier AB. Has botulinum toxin type A a place in the treatment of spasticity in spinal cord injury patients? Spinal Cord. 1998;36(12):854-858.
,
Has botulinum toxin type A a place in the treatment of spasticity in spinal cord injury patients?
,
Spinal Cord.
, vol.
36
(pg.
854
-
858
)
Abel NA, Smith RA. Intrathecal baclofen for treatment of intractable spinal spasticity. Arch Phys Med Rehabil. 1994;75(1):54-58.
,
Intrathecal baclofen for treatment of intractable spinal spasticity
,
Arch Phys Med Rehabil.
, vol.
75
(pg.
54
-
58
)
Kilgore KL, Foldes EA, Ackermann DM, Bhadra N. Combined direct current and high frequency nerve block for elimination of the onset response. Presented at: 31st Annual International Conference of the IEEE EMBS; September 2-6, 2009; Minneapolis, Minnesota.
World Health Organization. International Classification of Functioning, Disability and Health (ICF). Geneva, Switzerland: Author; 2002.
,
World Health Organization
,
International Classification of Functioning, Disability and Health (ICF).
Sinnott KA, Dunn JA, Rothwell AG. The use of the ICF for evaluation of outcome measures used in 10 year re-review following reconstructive hand surgery. Int J Spinal Cord. 2004;42(7):396-400.
,
The use of the ICF for evaluation of outcome measures used in 10 year re-review following reconstructive hand surgery
,
Int J Spinal Cord.
, vol.
42
(pg.
396
-
400
)
Bryden AM, Sinnott KA, Mulcahey MJ. Innovative strategies for improving upper extremity function in tetraplegia and considerations in measuring functional outcomes. Top Spinal Cord Inj Rehabil. 2005;10(4):75-93.
,
Innovative strategies for improving upper extremity function in tetraplegia and considerations in measuring functional outcomes
,
Top Spinal Cord Inj Rehabil.
, vol.
10
(pg.
75
-
93
)
Connolly SJ, Aubut JL, Teasell R, Jarus T. Enhancing upper extremity function with reconstructive surgery in persons with tetraplegia: a review of the literature. Top Spinal Cord Inj Rehabil. 2007;13(1):58-80
,
Enhancing upper extremity function with reconstructive surgery in persons with tetraplegia: a review of the literature
,
Top Spinal Cord Inj Rehabil.
, vol.
13
(pg.
58
-
80
)
Concato J, Shah N, Horwitz RI. Randomized, controlled trials, observational studies, and the hierarchy of research designs. N Engl J Med. 2000;342:1887-1892.
,
Randomized, controlled trials, observational studies, and the hierarchy of research designs
,
N Engl J Med.
, vol.
342
(pg.
1887
-
1892
)
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