Neurogenic urinary incontinence often results from loss of supraspinal inhibitory input that leads to involuntary bladder contractions (detrusor hyperreflexia). Recently, a novel approach has been used to "chemically" denervate the bladder. Botulinum-A toxin has been injected cystoscopically into neurogenic patients' bladder to treat refractory detrusor hyperreflexia and neurogenic incontinence. Reflex voided volumes, bladder capacities, and compliance increased while maximum detrusor pressures decreased. Continence was maintained for up to 6 months with anticholinergic agents eliminated or greatly reduced. Botulinum-A toxin detrusor injection appears to be a safe, minimally invasive, reversible, and effective treatment option for controlling detrusor hyperreflexia.
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Research Article|
January 01 2003
Botulinum-A Toxin Injections As a Treatment for Refractory Detrusor Hyperreflexia Free
Michael Kennelly;
Michael Kennelly
1
Director, Urology Department, Charlotte Institute of Rehabilitation, Charlotte, North Carolina.
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John Kang
John Kang
2
Urology Resident, Division of Urology, Department of Surgery, UNC-Chapel Hill, Chapel Hill, North Carolina.
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Top Spinal Cord Inj Rehabil (2003) 8 (3): 46–53.
Citation
Michael Kennelly, John Kang; Botulinum-A Toxin Injections As a Treatment for Refractory Detrusor Hyperreflexia. Top Spinal Cord Inj Rehabil 1 January 2003; 8 (3): 46–53. doi: https://doi.org/10.1310/1640-XEPP-Y33E-TMK8
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