Tire rolling resistance is one of the primary forces opposing motion on passenger vehicles. New regulations appearing around the world will provide information on tire rolling resistance to consumers. The linear relationship between fuel savings and rolling resistance has been previously demonstrated. Extensive testing in real-world driving conditions has validated previous models. The result is a measured sensitivity coefficient for North American usage, which relates the changes in vehicle fuel consumption of E10 gasoline to changes in rolling resistance. This sensitivity coefficient is shown to not be significantly different between a compact car, a medium-sized sedan, and a full-sized pickup truck. Results provide a simple and robust way for end consumers to predict the impact of tire choice on their fuel consumption and CO2 emissions using tire label information.