FIG. 1
Romiplostim (Nplate) reduces platelet nadir and hastens recovery of platelets and neutrophils in irradiated NHPs. Panels A and B: Platelet and neutrophil counts, respectively, in NHP administered Nplate (romiplostim), either alone or in combination with Neulasta (pegfilgrastim) are shown. Nplate (5 mg/kg) was given on day 1, and Neulasta was given on days 1 and 8 after TBI at an LD30/45 dose (5.50 Gy). Animals were first dosed 24 h after TBI. Modified figure presented [Published and modified, with permission, from: Wong K, Chang PY, Fielden M, Downey A-M, Bunin D, Bakke J, et al. Pharmacodynamics of romiplostim alone and in combination with pegfilgrastim on acute radiation-induced thrombocytopenia and nuetropenia in nonhuman primates. Int J Radiat Biol 2019. (In press)

Romiplostim (Nplate) reduces platelet nadir and hastens recovery of platelets and neutrophils in irradiated NHPs. Panels A and B: Platelet and neutrophil counts, respectively, in NHP administered Nplate (romiplostim), either alone or in combination with Neulasta (pegfilgrastim) are shown. Nplate (5 mg/kg) was given on day 1, and Neulasta was given on days 1 and 8 after TBI at an LD30/45 dose (5.50 Gy). Animals were first dosed 24 h after TBI. Modified figure presented [Published and modified, with permission, from: Wong K, Chang PY, Fielden M, Downey A-M, Bunin D, Bakke J, et al. Pharmacodynamics of romiplostim alone and in combination with pegfilgrastim on acute radiation-induced thrombocytopenia and nuetropenia in nonhuman primates. Int J Radiat Biol 2019. (In press)

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