Kinetic parameters correlate with in vivo data. Panel A: Schematic representation. The parameter ρ quantifies the fraction of repaired DNA damage, which relates to cell survival, while the parameter τ best correlates to the amount of misrepaired damage and subsequent cancer incidence. Panel B: Correlation between the survival rate of mouse B cells at 24 h after in vivo irradiation with 0.1 Gy X rays and the ρ coefficient obtained from ⁴⁰Ar and ⁵⁶Fe data combined for in vitro irradiated mouse fibroblasts, for the same 10 CC strains. Panel C: Pearson's correlation coefficients between the spontaneous cancer incidence data collected for four mouse strains in vivo from the MTB database and the τ coefficient obtained from mouse fibroblasts irradiated in vitro with 0.1 Gy X rays.