Fungal granulomas. A, Cryptococcus. Numerous round yeasts within histiocytes, some surrounded by haloes. B, Same case as A. Note pleomorphism and compare size with D and F. C, Coccidioides in a patient with disseminated coccidioidomycosis. Both endospore-filled and empty spherules are present. Note similarity of endospores to Cryptococcus (A) and of endospore-filled spherules to Blastomyces (E). D, Same case as C. E, Blastomyces. Single, large, thick-walled, nucleated yeast (arrow) within multinucleated giant cell. Note characteristic neutrophilic response. F, Same case as E. Large yeast with single broad-based bud (hematoxylin-eosin, original magnifications ×400 [A, C, and E]; Grocott methenamine silver, original magnifications ×400 [B, D, and F]).