Examination of differences in the timing of volume loss across brain structures demonstrating a significant difference in the volume change time course due to CRT (using a threshold of q < 0.01 based on a likelihood ratio test). Panel A: Structure-wise analysis of the timing of volume loss after cranial irradiation. The λ value unique to each structure is shown in the color map, and indicates the days required for 63% of the volume loss V0 to occur. Results indicated a significant difference in the timing of volume loss across gray and white matter structures (P = 0.023), with white matter volume loss emerging slower than gray matter volume loss. Panel B: Plot recapitulates results from panel A, but specifically compares gray and white matter differences in the timing of volume loss. The x-axis represents brain regions placed into two groups based on classification as gray matter (darker points) or white matter (lighter points). The y-axis represents the percent volume loss. Points in the plot represent distinct brain regions.
