Gross lesions in Lagovirus europaeus GI.2/RHDV2/b (rabbit hemorrhagic disease virus 2)–positive desert cottontails (Sylvilagus audubonii) (A, B) and black-tailed jackrabbits (Lepus californicus) (C, D) from Arizona, Texas, and New Mexico, USA, collected in April and May 2020. (A) There is blood around the nose (epistaxis). (B) The liver has indistinct areas of pallor with an enhanced reticular pattern and multifocal pinpoint red capsular foci (arrow). (C) The lung contains multifocal to locally extensive dark red areas (congestion and hemorrhage). (D) There are petechial hemorrhages on the cecal serosa.