maSigPro analysis of time-series gene expression data across the study. maSigPro graphs of the clusters and heat maps of gene signals (across time and injection groups) represent three clusters with the most disparity in expression response patterns, consistently down in cluster 1, switching from up to down in cluster 2 and consistently increasing in cluster 3. Two smaller clusters are shown in Supplementary Table S3, maSigPro clusters (https://doi.org/10.1667/RADE-20-00041.S4).