LSM1 and RAD5 are epistatic in response to UV irradiation. Cells from logarithmically growing cultures were plated on YPD plates, irradiated with increasing doses of UV radiation, and incubated in the dark to determine viability. lsm1Δ mutant in combination with (panel A) rad5Δ (average of three independent spores), (panel B) rad30Δ (average of three independent spores), and (panel C) rev3Δ (average of three independent spores). Error bars indicate SEM